european research peptides

Melatonin (90 tab)

Melatonin (5-metoxy-N-acetyltryptamín)
Melatonin (5-metoxy-N-acetyltryptamín)
Price:37.00
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Systematic (IUPAC) name: N-[2-(5-methoxy-1H-indol-3-yl)ethyl]

Molecular formula: C13H16N2O2

Molecular weight232.278 g/mol

Biological half-life: 35–50 minutes

 

Melatonin

Melatonin, chemically N-acetyl-5-methoxy tryptamine. In the synthesis of melatonin, tryptophan is hydroxylated to 5-hydroxytryptophan, which in turn is decarboxylated to 5-hydroxytryptamine (serotonin). Serotonin is converted to the melatonin precursor and metabolite Nacetylserotonin by the enzyme N-acetyl transferase. N-acetylserotonin is methylated via the enzyme hydroxyindole-methyltransferase to produce melatonin. In bacteria, protists, fungi, and plants melatonin is synthesized indirectly with tryptophan as an intermediate product of the shikimic acid pathway. In these cells synthesis starts with d-erythrose-4-phosphate and phosphoenolpyruvate, and in photosynthetic cells with carbon dioxide. The rest of the reactions are similar, but with slight variations in the last two enzymes. In vertebrates, melatonin secretion is regulated by norepinephrine. Norepinephrine elevates the intracellular cAMP concentration via beta-adrenergic receptors and activates the cAMP-dependent protein kinase A (PKA). PKA phosphorylates the penultimate enzyme, the arylalkylamine N-acetyltransferase (AANAT).